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Koperska A, Moszak M, Seraszek-Jaros A, Bogdanski P, Szulinska M

doi:10.1128/MCB.01704-07

159 SIRT1 alleviates ER stress by deacetylating molecules such as eIF2 and CHOP, 32 inhibiting excessive activation of the unfolded protein response, 160 and reducing expression of stress-related proteins including GRP78 and ATF4

The notable peptide vaccines that have undergone phase I/II/III clinical trials include HER-2/neu immunodominant peptide (lung, breast, or ovarian cancer) [6971], Mucin-1 (MUC-1, Stimuvax), peptide (breast or colon cancer) [72, 73], Carcinoembryonic antigen (colorectal, gastric, breast, pancreatic and non-small-cell lung cancers) [74, 75], Prostate-specific membrane antigen (prostate cancer) [7678], HPV-16 E7 peptide (cervical cancer) [79], Ras oncoprotein peptide (colorectal and pancreatic carcinomas) [8082], and Melanoma antigens (Melanoma) [62, 68, 8385]