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To elucidate how impaired IGF- 1 input affects skeletal muscle vasculature, we examined the effects of endothelial-specific IGF- 1 receptor (IGF- 1R) deficiency using a mouse model of endothelial IGF- 1R knockdown (VE-Cadherin-CreER T2 /Igf1r f/f mice)

Novel ETF dehydrogenase mutations in a patient with mild glutaric aciduria type II and complex II-III deficiency in liver and muscle

In recent years, astrocyte-targeted therapeutic approaches have expanded from preclinical interventions to early clinical trials

Besides being the sole antioxidant enzyme able to repair lipid peroxides, GPX4 is a moonlighting protein that also regulate eicosanoid biosynthesis ( Hydroperoxides relevant to inflammation are those formed from arachidonic acid (AA) by stereoselective lipoxygenases