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Sensitivity study Limit of determination and limit of quantification: The LOQ is the lowest amount of the NAC and Di-NAC in the sample that can be confidently quantified using the method

Blood was first diluted 1:1 in PBS, and PBMCs were isolated using SepMate-50 separation tubes (STEMCELL Technologies) according to the manufacturers instructions

Given how hard it is to get these medications for some patients, this can be an attractive alternative, but the FDA has expressed concern at the frequency of -glutide salts turning up in compounded formulations, which are not present in any of the FDA-approved drugs and thus have an unknown safety and efficacy profile

The increased baseline level of misfolded -synuclein aggregate in CSF (measured by protein misfolding cyclic amplification technique) has been reported in a follow-up study as a risk factor for the development of dementia in PD (Ning et al., 2019)