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Causes of Stevens-Johnson syndrome Stevens-Johnson syndrome is often caused by your body reacting to certain medicines, particularly some types of: epilepsy medicines antibiotics anti-inflammatory painkillers Medicines commonly linked to Stevens-Johnson syndrome allopurinol carbamazepine lamotrigine nevirapine oxicam anti-inflammatories, such as meloxicam and piroxicam phenobarbital phenytoin sulfamethoxazole and other sulfa antibiotics sulfasalazine In children, Stevens-Johnson syndrome can sometimes be caused by infections like a cold or flu, cold sores and glandular fever