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It can be observed that bioactive compounds are able to suppress MITF or TYR activity by either binding to transcription factors directly or by inhibiting melanogenic pathways upstream, including that of cAMP/PKA, ERK, Wnt/-catenin and MAPK

(2007) The association between betaine and choline intakes and the plasma concentrations of homocysteine in women, Am J Clin Nutr, Vol.84, No

Children with autism have low levels of glutathione, and often have impaired glutathione detox pathways

Ashwagandha also influences monoaminergic systems, but its effects are largely indirect, arising from normalization of hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, modulation of GABAergic tone, and attenuation of stress-induced neurotransmitter imbalance