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Potential Complementary Effects When used together, these medications may address weight loss from two different angles
However, in some cases, biopsy is necessary and occasionally, immunohistochemical stains such as melanocyte marker HMB-45 and macrophage marker CD68 may be required to prompt a correct diagnosis
This off-label use, the authors argue, is exposing deeper tensions between medical innovation, weight stigma, and the social value attached to thinness, as medication becomes a means of attaining social and aesthetic goals rather than improving health
The SUSTAIN-7 trial showed that people taking both semaglutide and metformin achieved greater HbA1c reductions and weight loss than those using either drug alone, with average additional weight loss of 4 to 6 kilograms
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