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Common requirements include documented BMI meeting the threshold, proof of previous weight loss attempts (usually 3-6 months of supervised diet and exercise), at least one qualifying comorbidity, and sometimes evidence that other treatments have been tried and failed

The resolution of this apparent paradox is that glucagon receptor activation also drives energy expenditure through two well-documented mechanisms: Thermogenesis: GCGR activation in brown adipose tissue (BAT) and, to a lesser extent, skeletal muscle increases uncoupled heat production, raising resting energy expenditure

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