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Hayes asked whether the GLP-1 receptors develop a tolerance similar to what is seen with opioid receptors in the brain

Abstract Corticotropin-releasing factor (CRF) is the hallmark brain peptide triggering the response to stress and mediatesin addition to the stimulation of the hypothalamus-pituitary-adrenal (HPA) axisother hormonal, behavioral, autonomic and visceral components

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Compared to the models, the mice in the S-0.42 group and S-0.84 groups showed significant weight loss, with the S-0.84 group showing even more significant weight loss