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The reason for this restriction is that as previously described, the age-related decline in function of the GH neuroendocrine axis is accepted as being a normal part of aging, even though it is progressively detrimental to many aspects of body function

This approach may reduce estrogen spikes and provide more stable testicular stimulation

Some practitioners report using the two compounds at different phases of a research protocol, with DES associated with focused local interventions and LR3 used as a systemic anabolic agent