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Studies have shown that colorectal cancer liver metastasis (CRLM) PDOs can highly preserve the histopathological and molecular characteristics of primary tumors while successfully capturing intra- and inter-patient heterogeneity [180]

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the membrane potential was held at -70 mV at room temperature (25C) during a period of 0.5 - 2 h after removal of the culture from the incubator

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