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This issue highlights key shifts shaping global and Korean markets: The global pharmaceutical markets pivot toward metabolic diseases and the post-GLP-1 competitive era China surpassing the US in new drug approvals, intensifying global biotech competition Rapid growth of Koreas CGM market, alongside continued import dependence Major outcomes from Koreas pan-ministerial medical device R&D program and the launch of its second phase A 1 trillion government investment in medical AI and expanded real-world implementation MFDS regulatory updates, including new drug & biotech guidelines, digital clinical data guidance, updated trial site designations, WHO WLA recognition, and direct government supply of rare medicines Together, these developments signal a more data-driven, innovation-focused, and globally connected clinical and regulatory environment