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In the SURMOUNT-1 trial, participants taking the highest dose of tirzepatide (15 mg weekly) lost an average of 22.5% of their body weight over 72 weeks

Although the key role of LOXs in ferroptosis is still controversial, certain LOXs can catalyze the stereospecific addition of oxygen onto PUFAs (Kuhn et al., 2005), indicating LOXs may mediate ferroptosis

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Five studies could not be included in the quantitative synthesis because they did not report depressive-symptom outcomes with the summary statistics needed to calculate the effect size