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Taken together, evidence of early locus coeruleus pathology in AD and PD, reductions in norepinephrine transporters with aging, AD and PD, and robust norepinephrine transporter engagement by antidepressants point to the norepinephrine transporter as a critical, yet understudied target in LLD [169, 178]

( Previous alkylation studies of GSTA1 focused on in vivo binding of bromobenzene metabolites to Cys112 in rat (Koen et al., In comparison to our findings of NAPQI-modified Cys78 in GSTM1, Nerland et al

Although the mass spectrometry was initially carried out on livers from male mice, we hypothesized that ibuprofen would cause similar effects on livers from female mice