This poor absorption profile is precisely why standard mineral supplements often cause severe gastrointestinal distress
The underlying mechanism may be related to GSH metabolism (163), abnormal iron metabolism (164), lipid peroxidation (165) and mitochondrial dysfunction (166)
Volkova A et al., 2016 [PubMed] Key Areas of Research: Molecular Tuftsin receptor binding characterization, GABAergic gene expression profiling, peptide structural stability assays in biological matrices, angiotensin-converting enzyme interaction mapping, enzymatic cleavage resistance characterization Cellular / Neurochemical GABAergic signaling pathway characterization, inhibitory neurotransmission parameter assessment, neuroblastoma cell line gene expression profiling, GABA receptor interaction modeling, anxiolytic-relevant receptor system characterization in preclinical settings Systemic (Preclinical) Behavioral parameter measurement in anxiety-relevant preclinical models, cytokine pathway modulation monitoring, neuroimmune axis interaction characterization, inhibitory signaling system profiling in controlled investigational settings Together, these findings suggest broad experimental potential for Selank across GABAergic neurotransmission, neuroimmune signaling, and preclinical anxiety-model research pathways
doi: 10.3389/fphar.2020.578396 77 PasierskiM.SzulczykB
