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While recent studies suggest a potential association among hyperuricemia, cardiovascular and renal diseases, further research is needed to elucidate the mechanisms and clinical benefits of urate-lowering therapy in these populations

Compared with normal hepatic function, the estimated ratio of the mean AUC 0 was 0.99 (0.891.11) in mild impairment, 1.01 (0.911.12) in moderate impairment and 1.11 (0.961.30) in severe impairment

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