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Disease states, including iron-deficiency anemia (Ramachandran and Iyer, 1974), severe uremia, cirrhosis of the liver, and hypothyroidism lead to increased erythrocyte glutathione reductase activity

For adults with a BMI of 40 kg/m2 or higher or those with a BMI of 35 kg/m2 or higher with obstructive sleep apnea or prediabetes, Apovian recommends strongly considering bariatric surgery as a first-line therapy due to very low complication rates and robust and durable weight loss

Cells within adenomas may reveal signs of degenerative processes such as intracytoplasmic-inclusions, hyaline bodies, or vacuoles

RAI can also be introduced by moving straight to a basal-bolus regimen