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Limitations and perspectives Therapeutic approaches targeting cardiac remodeling reversal, including monoclonal antibodies, peptide-based therapies, and AAV vectors, share similar translational challenges with cardiac regeneration strategies, particularly with respect to delivery efficiency and potential off-target effects

A safety signal emerged during clinical development: a separate obesity trial program using a related CJC-1295 compound was reportedly halted after a death, underscoring that long-term human safety is not established