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Inhibitory KORD-DREADD expression in the OB resulted in increased chow intake in RD mice, whereas excitatory hM3Dq-DREADD induced a decreased chow and high-fat high-sucrose diet in WD mice

These include: Research and Nooms internal data indicate that combining GLP-1s with behavior-change support yields better, more durable outcomes than medication alone

Weigh yourself at the same time of day, ideally weekly rather than daily, to avoid discouragement from normal fluctuations

doi: 10.2337/db21-0848 Summary Keywords GLP-1 - glucagon-like peptide-1, GIP - glucose-dependent insulinotropic peptide, obesity, incretin, pharmacology Citation Douros JD, Flak JN and Knerr PJ (2025) The agony and the efficacy: central mechanisms of GLP-1 induced adverse events and their mitigation by GIP