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Among these, TERT emerged as the most prominent target, supported by multiple clinical-stage candidates, such as the immuno-oncology vaccine UV-1 (Phase II) and the direct telomerase inhibitor ateganosine (Phase II)

Mechanism of Action Metformin decreases hepatic glucose production and improves hepatic insulin sensitivity but has only a modest impact on peripheral insulin-mediated glucose uptake (i.e., insulin resistance), which is likely due to a reduction in hyperglycemia, triglycerides, and free fatty acid levels (48,49)

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Side effects are typically mild and digestive in nature, such as temporary stomach discomfort, and are often minimized by proper dosing and consistency