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The most common laboratory tests for MCAS include: Serum tryptase : An enzyme released by activated mast cells N-methylhistamine : A breakdown product of histamine measured in 24-hour urine Prostaglandin D2 or its metabolites: Measured in blood or urine Leukotriene E4 : Measured in 24-hour urine Chromogranin A : A marker for neuroendocrine activity It's important to note that many MCAS patients have normal tryptase levels between reactions, and some have normal levels even during reactions

141 Martagon AJ, Lin JZ, Cimini SL, Webb P, Phillips KJ