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Fatigue, Sleep Loss, & General Cognition Certain patients may undergo treatment for six to twelve months to take advantage of additional anti-aging effects, such as increased overall energy levels, improved sleep, enhanced cognition, and even greater body composition improvements

Moreover, estrogen has positive effects on the viability of skin fibroblasts, and by inducing the expression of transforming growth factor-beta (TGF) and tissue inhibitor of matrix metalloproteinases (TIMPs), and inhibiting matrix metalloproteinases (MMPs), E2 stimulates the production and maintenance of extracellular matrix components, such as collagen type I and III and fibrillin (Lephart and Naftolin, 2021)

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