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No, the modest heart rate increase has not been associated with increased cardiovascular risk in large clinical trials

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CrossRef Untapped Pharmaceutical Potential of 4,5,4-Trihydroxy-3,3-dimethoxybibenzyl for Regulating Obesity: A Cell-Based Study with a Focus on Terminal Differentiation in Adipogenesis Hnin Ei Ei Khine, Rungroch Sungthong, Boonchoo Sritularak, Eakachai Prompetchara, Chatchai Chaotham Journal of Natural Products.2022