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Lichtenberg 1988)
The extracellular citrulline autoantigen present in the joints of RA patients is mainly derived from the increased NET, which can cause the inflammatory response of synovial fibroblasts in patients and release a series of inflammatory mediators (such as pro-inflammatory cytokines, adhesion molecules and chemokines) to drive the progression of RA (205)
299 , 300 , 301 , 302 , 303 (See Detection, Screening, and Diagnosis in the Workforce section for a discussion of barriers to timely and accurate diagnosis from the perspective of primary care physicians.) Because dementia is often underdiagnosed and if it is diagnosed by a clinician, some people appear to be unaware of their diagnosis a large portion of Americans with dementia may not know they have it
