soul trial oral semaglutide cardiovascular outcomes nejm 2024 2025

soul trial oral semaglutide cardiovascular outcomes nejm 2024 2025 Reduces Events in People with Type 2 Diabetes with Atherosclerotic Cardiovascular and/or Chronic Kidney Disease: Primary Results From the Randomized Oral Semaglutide and Cardiovascular Outcomes

Name: soul trial oral semaglutide cardiovascular outcomes nejm 2024 2025 Reduces Events in People with Type 2 Diabetes with Atherosclerotic Cardiovascular and/or Chronic Kidney Disease: Primary Results From the Randomized Oral Semaglutide and Cardiovascular Outcomes
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Description

This peptidase degrades GLP-1 (7-36)-amide into smaller peptides including GLP-1 (28-36)-amide and GLP-1 (32-36)-amide [31]

[1] [2] The mechanism by which semaglutide may contribute to burping primarily relates to its effect on gastric emptying

Additionally, extreme caloric restriction combined with GLP-1's appetite suppression may deprive the brain of adequate nutrition and neurotransmitter precursors needed for stable mood

Due to their long half-lives, traces may remain in the system for multiple weeks after discontinuation