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Now, does that automatically make them unsafe

Although sulfonylureas are associated with slightly greater upfront reductions in glycosylated hemoglobin levels (HbA1c, 1% to 1.25% reduction) relative to metformin (0.5% to 1.25%) (23) in the UKPDS study, after 6 months, reduction in a1c levels were similar between groups on either therapy

While no diabetic ketoacidosisa life-threatening complication of diabetesor severe hypoglycemia occurred during the trial, there were two episodes of recurrent high ketone levels without high blood sugars or acidosis that occurred while participants were using semaglutide

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