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Intriguingly, cereulide productivity in medium to high producers seem to be inversely correlated with the total abundance of released tetra-, octa- and dodecadepsipeptide esters measured as a proxy for NRPS-bound depsipeptides

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In summary, tumor cells establish a remarkably stable and adaptive MDR network not through the isolated action of single pathways, but via the dynamic interweaving and remodeling of multiple core survival circuits, including PI3K/AKT/mTOR, MAPK, JAK-STAT, and NF-B

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