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The SELECT trial's cardiovascular benefit data (20% MACE reduction) has been particularly influential in changing payer attitudes, because preventing heart attacks and strokes saves money long-term
Preclinical studies have shown that GKT137831 (setanaxib), a dual inhibitor of Nox1 and Nox4, exhibits renoprotective effects by attenuating glomerular structural changes, podocyte loss, extracellular matrix accumulation, and albuminuria in a mouse model of diabetic nephropathy [61,62]
The rest of the PATs mostly showed ER localization, while zDHHC4 was associated almost exclusively with the nuclear envelope (Supplementary Fig
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