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Efficacy markers to track Weight loss rate provides the most obvious efficacy signal

The electron transport chain consumes up to 90% of total oxygen (O 2 ) taken up by the cells (Wallace, 2013)

20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO SECTION 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of February, 2026 Commission File Number: 001-36815 Ascendis Pharma A/S (Exact Name of Registrant as Specified in Its Charter) Tuborg Boulevard 12 DK-2900 Hellerup Denmark (Address of principal executive offices) Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F

These medications are usually injected and may be: Formally approved by the FDA for certain conditions (such as type 2 diabetes or weight management), or Used off-label for conditions they are not officially approved forsuch as weight loss when the labeled indication is diabetes