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During this process, the mitochondrial matrix reductase ferredoxin 1 (FDX1) functions as a critical upstream regulator by reducing Cu 2 + to the more toxic Cu + species and by promoting LIAS-mediated protein lipoylation

It can be difficult to successfully replenish glutathione with capsule delivery methods

The degradation of glutathione by GGT recruits amino acids, notably Cys, to cells, but also produces -glutamyl peptides extracellularly under certain circumstances

The neuroprotective effect of amifostine has been demonstrated in some clinical trials for platinum- and paclitaxel-induced neurotoxicity [148, 149]