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8 Specifically, the FDA voiced concern about investigational plan deviations to enroll subjects who did not meet eligibility criteria, which jeopardizes subjects safety and welfare and raises concerns about the validity and integrity of the data collected

There have also been reports of thyroid tumors in animal studies, though this has not been confirmed in humans

The Nrf2 pathway is a key player in the antioxidant response to ROS accumulation that regulates glutathione peroxidase (GSH), heme oxygenase-1, NADPH oxidase (NOX) and several other critical pathways [80]

Mauer J, Denson JL, Bruning JC (2015) Versatile functions for IL-6 in metabolism and cancer