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While these synthetic GLP-1 agonists have demonstrated remarkable efficacy in clinical trials, they are associated with a range of side effects, including common gastrointestinal issues such as nausea, vomiting, diarrhea, and constipation, which are often dose-dependent (Kommu S et al., 2025

In contrast, HNF4-positive epithelial liver cancer lines were sensitive to sorafenib treatment when cultured in complete medium, and this sensitivity was further augmented by lowering medium concentrations of methionine/cystine (Fig

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However, Lilly indicated they would in 2025 be published in a peer-reviewed journal and presented at an unspecified medical meeting