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A growing body of evidence suggests that GLP-1 has anti-inflammatory actions independent of its metabolic actions

The LEAN study was the first to demonstrate that liraglutide 1.8 mg induced histological resolution of MASH compared to placebo in a small group of patients with and without diabetes 93

In terms of weight loss effectiveness , semaglutide GLP-1 does have an edge over liraglutide, according to current research

They function as insulin sensitizers by activating the peroxisome proliferator-activated receptor gamma (PPAR-), a type of nuclear receptor that plays a crucial role in the regulation of glucose and lipid metabolism