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Multivar Behav Res 46(3):399424 Carolino IDR, Molena-Fernandes CA, Tasca RS, Marcon SS, Cuman RK N (2008) Risk factors in patients with type 2 diabetes mellitus

The GH pulse profile they create doesn't match the sustained elevation required for IGF-1-mediated anabolism

For example, Jessen et al 132 demonstrated that central administration of GLP-1 increased neuronal activity in brain regions (PVN and NTS), thereby mediating autonomic nervous system, as well as activation of HPA axis and stimulation of circulating levels of corticosterone and epinephrine