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The interaction between the leaving P i and R359 induces the dissociation (state A) and re-association (state B) of F360 with respect to helix 407423 and thereby increases the plasticity of the arginine finger loop and the entire active site

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Inhibiting the NLRP3 inflammasome with MCC950 ameliorates retinal neovascularization and leakage by reversing the IL-1beta/IL-18 activation pattern in an oxygen-induced ischemic retinopathy mouse model