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Keywords: pernicious anemia, acute hemolytic anemia, intensive & critical care, hematology-oncology, obstructive shock, intrinsic factor, hyperhomocysteinemia, acute pulmonary embolism, vitamin b 12 deficiency Introduction Vitamin B12, also known as cobalamin, is a water-soluble vitamin that serves as a cofactor in DNA synthesis [1]

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MC1R activation upregulates tyrosinase and other melanogenic enzymes, and new eumelanin accumulates in melanocytes over days

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