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SURMOUNT-2 (tirzepatide in type 2 diabetes with obesity) reported similar constipation rates and confirmed that GI events clustered around dose-escalation windows

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TMAO, trimethylamine-N-oxide

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Similar content being viewed by others Background GLP-1 receptor agonists have transformed the therapeutic landscape for both type 2 diabetes mellitus and obesity, primarily by modulating appetite and gastric emptying to facilitate weight loss [1]

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