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The Billon 2025 paper (PMID 41421047) is the citation that anchors the route question: SLU-PP-915 was developed because SLU-PP-332 "lacks oral bioavailability." If the parent compound does not absorb orally, oral capsules and tablets are unlikely to produce the systemic ERR agonism seen in mice

Possible long-term effects are one of the things that concern Adam Meakins, a U.K.-based physiotherapist and strength and conditioning coach who has worked with clients using BPC-157

It is also possible that hypothalamic/pituitary autoimmunity may be present in ME/CFS- particularly in the more severe cases- as antipituitary and antihypothalamic antibodies have been identified (430)

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