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The predicted toxicity risks indicated that none of the tested compounds showed any irritant effects, however, compound 25 exhibited a high tumorigenic potential, and compounds 21 , 24 , and 25 demonstrated a high mutagenic probability [58]
Red flag symptomsincluding severe abdominal pain, rectal bleeding, unintentional weight loss, or a significant change in bowel habitrequire prompt medical assessment to exclude serious underlying pathology
However, due to slow disease progression and employee turnover, immediate ROI remains uncertain