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Concentrations were then corrected for these with the following formula: where [Mcorr] is the corrected concentration, [M] is the water-referenced metabolite concentration from the LCmodel output, fCSF is CSF fraction in the voxel, fGM is GM fraction in the voxel, and fWM is GM fraction in the voxel

One compound reduces energy intake, the other increases energy expenditure at the mitochondrial level

The two effects address different rate-limiting steps of repair

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