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It means they benefit from co-supplementation with methylated B vitamins (methylcobalamin, 5-MTHF, P5P) to support the homocysteine clearance pathway during the adaptation window

Focused formulation is different

doi: 10.1016/j.nlm.2019.107151, 111 ScheltensP.De StrooperB.KivipeltoM.HolstegeH.ChetelatG.TeunissenC