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However, many of these inhibitors, such as RSL3 and ML162, have exhibited suboptimal pharmacological properties in preclinical animal models, while others like BSO and auranofin have not yielded the desired anti-cancer effects in clinical trials, limiting their potential for clinical translation or application

This approach has been used by others and is recommended for all noninvasive space-occupying subungual lesions, regardless of type

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FDA evaluates a nominated substance using a balancing test that includes characterization, safety issues, available evidence of effectiveness or lack of effectiveness, and historical use