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Patients with asthma represent a relative contraindication group, as bronchospasm has been reported in susceptible individuals following parenteral administration

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Vitamin B12 is an essential water-soluble vitamin used throughout the body in functions such as brain function, red blood cell production, DNA production, and more

These recommend not regularly drinking more than 14 units of alcohol per week , spread over three or more days, with several alcohol-free days each week