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Any insurance policy is likely to cover a drug only for its FDA-approved use, so in most cases, Aetna will cover metformin only for individuals diagnosed with Type 2 diabetes

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In a study that examined data from 13,351 participants in the National Health and Nutrition Examination Study (NHANES), higher serum folate levels were associated with a 50% lower likelihood of having experienced a severe headache or migraine in the previous three months (Luwen 2024)