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We knock out Gipr in either the area postrema (AP) or hypothalamus of mice (Gipr AP-KO and Gipr hypo-KO , respectively) and compare body weight and food intake responses to GIPR agonists and antagonists, alone and in combination with the GLP-1R agonist liraglutide

Adipose Tissue Research Used in models assessing: Adipocyte differentiation Hormonal regulation of fat cells Gene-expression patterns linked to metabolism These findings come from preclinical and in-vitro studies and are not validated clinical outcomes

needles should be changed before administration