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Neurology 70 , 14381444 (2008)

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Rather than aggressive calorie restriction, which risks malnutrition and muscle loss, a moderate energy deficit of 500-600 calories per day is generally recommended

As GLP-1 agonists contribute to glycaemic control by potentiating glucose-dependent stimulation of insulin secretion from pancreatic cells 21 , we compared the effects of the biased agonist P5 with Ex4 on plasma insulin levels in response to the glucose challenge