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JCI Insight 4, e127709

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Patient awareness gaps drive poor treatment decisions: Limited knowledge that no IV glutathione is FDA-approved for skin lightening Lack of awareness about the 32% adverse event rate including serious complications Aesthetic clinic promotion continues despite regulatory warnings from multiple countries Misconception that higher cost ($2,000-$3,200) equals better results The 2025 Philippine FDA warning states there are no published guidelines for appropriate dosing regimens