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Over time, this makes it easier to follow a calorie-controlled diet without constant hunger, allowing for steady, realistic weight loss that feels manageable and sustainable
Some patients take them long-term for maintenance, while others taper off under medical guidance after achieving goals
Of 274 participants, 91% reported reduced overall food cravings at six weeks
However, the numerous central effects described for native GLP-1 and for some of the GLP-1RAs in rodents and in humans encourage future clinical trials exploring additional mechanisms that could potentially underlie the beneficial effects observed with this drug class
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