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Tukhovskaya EA et al

An analysis of data from 19 clinical trials of vitamin E found a higher mortality rate in trials where patients took more than 400 IU (=268 vitamin E/day) via supplementation

Your body naturally produces this amino acid, and it is also found in many foods

Furthermore, analysis of UK Biobank data showed associations between MDD PRS and metabolic markers such as HbA1c and glucose levels, which are relevant to diabetes pathophysiology, although these associations became non-significant in fully adjusted models [67]