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Where sterile water becomes the wrong choice is in any multi-dose scenario without a preservative, each additional needle insertion introduces contamination risk that compounds over time

Because your body uses and excretes B12 rather than storing unlimited amounts, consistent timing helps keep your energy and focus steady instead of peaking and crashing. Many people find that taking B12 late in the day can make them feel more alert right when they are trying to wind down, which may interfere with sleep

Oral supplementation with 1000-2000 mcg daily is often effective, though severe deficiency may require intramuscular injections

Sometimes people can take high doses of oral B 12 to provide replacement instead of undergoing injections, but a physician should closely supervise this