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Pharmacological inhibition of the NLRP3 inflammasome suppressed PFKFB3-driven glycolysis and vice versa, resulting in decreased lactate production in TGF-1 + IL-1-stimulated lung fibroblasts

7.3 Transgenerational and epigenetic research priorities While animal studies consistently demonstrate heritable reproductive dysfunction through EED-induced epigenetic modifications, human evidence remains limited, necessitating focused research initiatives to validate these mechanisms in human populations

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Because carnitine is involved in the metabolism of long-chain fatty acids, a carnitine deficiency may contribute to the development of fatty liver